Risk assessment in interstitial lung disease: the incremental prognostic value of cardiopulmonary ultrasound

Abstract Background The mortality risk of chronic interstitial lung disease (ILD) is currently assessed using the ILD-GAP score. present study evaluates whether addition cardiopulmonary ultrasound parameters to score can further improve predictive value ILD-GAP. Methods Medical records from 91 patients with ILD hospitalized June 2015 March 2016 were retrospectively examined. Lung (LUS) score, right ventricular (RV) function, and mechanics obtained ultrasound. was calculated demographic characteristics pulmonary function parameters. Patients followed up until May 2020. primary endpoint all-cause death. Results After exclusions, 74 included in analysis. During follow-up period, 36 survived (ILD s ), 38 died d ). Compared , cases exhibited a higher number B-lines, LUS RV end-diastolic base dimension (RVD), but lower function. In multivariate analysis, (hazard ratio, 2.88; 95% CI 1.38–5.99, P = 0.005), ratio 1.13; 1.04–1.24, 0.006), RVD 1.09, 1.03–1.16, 0.004) significantly related Adding improved compared alone (C statistics 0.90 vs 0.76, 0.018). Conclusion We investigated utility new prognostic model for that includes both (LUS RVD) This better reflects severity fibrosis cardiac involvement, has incremental over alone.